21 Female Actors Whose Onscreen Chemistry In Movies And TV Was So Amazing They Deserved An Award thumbnail

21 Female Actors Whose Onscreen Chemistry In Movies And TV Was So Amazing They Deserved An Award

Name a more iconic duo than Jane Fonda and Lily Tomlin. I dare you.

We asked the BuzzFeed Community to tell us which famous women had the best onscreen chemistry in movies and TV shows. Here are the amazing results.

Warning: Potential spoilers ahead! 🚨

1.

Sandra Oh and Ellen Pompeo as Cristina and Meredith on Grey’s Anatomy (2005–present)


ABC

“Their time together on Grey’s was hilarious and heartfelt and authentic and genuine all at the same time, and it’s all because of their onscreen chemistry. They were true to each other, they voiced their opinions when needed, and even through their fights, they’d make sure that the one another was okay. I think they’re the best!”

geenelychanga

2.

Regina Hall and Anna Faris as Brenda and Cindy in Scary Movie 2 (2001)


Dimension Films

Suggested by: rosalesgoninfa

I can literally watch the Scary Movies over and over again because of Regina Hall and Anna Faris’ chemistry alone. They looked like they worked so well together, and they constantly made us laugh with their quick one-liners and facial expressions — I would kill for a reunion!

3.

Julie Andrews and Anne Hathaway as Queen Clarisse and Mia Thermopolis in The Princess Diaries (2001)


Buena Vista Pictures

“Honestly, Anne Hathaway and Julie Andrews’ onscreen chemistry doesn’t get talked about enough. They were the best in The Princess Diaries.”

alexfromjupiter

4.

Tisha Campbell and Tichina Arnold as Gina and Pam in Martin (1992–1997)


Fox

“Whenever they showed up together in a scene, you knew it was gonna be hilarious and upbeat, and it was gonna sound hella good because both of these ladies can sing, okay?! And, they’ve been best friends for decades, so their onscreen chemistry was transparent!”

sjward21

5.

Margot Robbie and Kate McKinnon as Kayla and Jess in Bombshell (2019)


Lionsgate

6.

Shay Mitchell and Bianca Lawson as Emily and Maya on Pretty Little Liars (2010–2017)


Freeform

“Out of all of Emily’s girlfriends, Maya was the best. Paige tried to drown her and Alison was a jerk toward her, but Maya was the only one who treated her right. And though she ‘died,’ we never saw a body, and on this show, even seeing a body didn’t mean death — so she can still be alive if they ever do a reunion 😉.”

Ask_Aspie

7.

Jane Fonda and Lily Tomlin as Grace and Frankie on Grace and Frankie (2015–present)


Netflix

“They were funny together in the beginning when they didn’t like each other, and it’s been a joy to watch them become best friends (and they’re still funny). There aren’t enough shows centered around older female friendships!”

firecat40

8.

Tatiana Maslany and Évelyne Brochu as Cosima and Delphine on Orphan Black (2013–2017)


BBC America

“While I loved all of the relationships between the clones — I mean, Tatiana Maslany literally had chemistry with herself — Tatiana and Évelyne Brochu’s onscreen chemistry was undeniable. I still think about Cosima and Delphine to this day.”

noradominick

9.

Mary-Louise Parker and Mary Stuart Masterson as Ruth and Idgie in Fried Green Tomatoes (1991)


Universal Pictures

“Their dynamic in the film was unparalleled. Watching them grow together and as individuals is, in my opinion, what real friendship is all about.”

graycinquillin

10.

Angela Bassett and Whoopi Goldberg as Stella and Delilah in How Stella Got Her Groove Back (1998)


20th Century Fox

“Angela Bassett and Whoopi Goldberg’s chemistry in this ’90s classic was unmatched, and every scene they were in together was hilarious, smart, and beyond perfect. I just wish Whoopi Goldberg’s character didn’t die so soon in the movie — I needed more scenes with them!!!”

kaylayandoli

11.

Melissa Fumero and Stephanie Beatriz as Amy and Rosa on Brooklyn Nine-Nine (2013–present)


NBC

“They’re the greatest combination of actors, and have done such a good job showing how women support each other in a profession dominated by men.”

sweetessence786

12.

Jamie Clayton and Freema Agyeman as Nomi and Amanita on Sense8 (2015–2018)


Netflix

“Amanita and Nomi from Sense8! They were just so in love and deeply connected to each other that I literally sometimes forgot they were actors. The chemistry was wonderful, and their genuine interactions were just the sweetest and most tear-jerking ever.”

koontzk87

13.

Mira Sorvino and Lisa Kudrow as Romy and Michele in Romy and Michele’s High School Reunion (1997)


Buena Vista Pictures

“Their chemistry was undeniable — they both had impeccable comedic timing, and they’re gorgeous to boot. The characters were absolutely iconic, and that movie is still a classic.”

shauna_malwae-tweep

14.

Jodie Comer and Sandra Oh as Villanelle and Eve on Killing Eve (2018–present)


BBC America

“Sandra Oh and Jodie Comer as Eve and Villanelle in Killing Eve — they’re *chef’s kiss* perfection 👌.”

logea022311

“Eve and Villanelle from Killing Eve. Their chemistry was undeniable, and every time they were in a scene together, the tension was so palpable.”

MetropolisJo

15.

Cate Blanchett and Rooney Mara as Carol and Therese in Carol (2015)


StudioCanal / The Weinstein Company

“This was literally one of the best onscreen relationships I’ve EVER seen.”

callmeoreo

16.

Whitney Houston and Brandy as Fairy Godmother and Cinderella in Rodgers & Hammerstein’s Cinderella (1997)


Walt Disney Television

Suggested by: spenceralthouse

No one else could’ve brought Cinderella and the Fairy Godmother to life in this remake like Brandy and Whitney Houston did. They were so in sync with each other, and their onscreen chemistry was undeniable — that definitely had a lot to do with their friendship offscreen. The behind-the-scenes clip of them rehearsing “Impossible” in the music studio will forever be magical!

17.

Maya Erskine and Anna Konkle as Maya and Anna in PEN15 (2019–present)


Hulu

“I’m so mad it took me until 2021 to watch PEN15, but oh my god, I’m so glad I’m here. Maya Erskine and Anna Konkle have the best onscreen chemistry I’ve seen between two actors in a long, long time — they’ve made me laugh and cry in a matter of seconds, and I hope they continue to work on more projects together in the future! They’re a brilliant beyond brilliant pair.”

kaylayandoli

18.

Kaitlyn Dever and Diana Silvers as Amy and Hope in Booksmart (2019)


United Artists Releasing

19.

Amy Poehler and Rashida Jones as Leslie and Anne on Parks and Recreation (2009–2015)


NBC

“Amy Poehler and Rashida Jones made these characters serious friendship goals, even when Leslie and Anne didn’t agree with each other — they supported each other wholeheartedly. They were always honest and thoughtful, and I loved their chemistry!”

maureenr4311f2759

20.

Sanaa Lathan and Alfre Woodard as Monica and Camille in Love & Basketball (2000)


New Line Cinema

“They’ve played an incredible mother and daughter pair in multiple movies, like Something New, The Family That Preys, and Love & Basketball!”

yessirbrebre_26

21.

And Naya Rivera and Heather Morris as Santana and Brittany on Glee (2009–2015)


Fox

“Their chemistry both on- and off-screen was the reason for Brittana’s relationship to become canon, and it ended up being one of the most groundbreaking ships on TV.”

beppa10

Note: Submissions were edited for length and/or clarity.

Which female actors do you think had the best onscreen chemistry in a movie or TV show? Let us know in the comments below!

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